Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.
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Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International
To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of liquisolid systems has been developed by Spireas [ 78 ]. December 24, Citation: Cumulative percent drug release was plotted as a function of time, and percent drug release in 5 minutes was calculated. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate.
View at Google Scholar I. From the results of different batches prepared by three different carriers shown in Table 6 cimpacts, it was found that Neusilin proved to be the superior carrier than liquisoliid.
Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption capacity increases by many folds. The weight of formulations containing Neusilin and Fujicalin ranged in between 0.
The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. As highest drug release rates are observed with liquisolid compact system and this system may be optimized by selection of the liquid vehicle and the carrier and coating materials. Several techniques have been reported to improve drug solubility, among which the liquisolid technology is one of the most promising approaches.
Agri and Aquaculture Journals Dr. The flowable liquid retention potential was calculated using the following equation: Angle of slide determination is an important step in the formulation of liquisolid tablets. View at Google Scholar.
Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers
As a most discussed but still not completely resolved issue, solubility or dissolution enhancement techniques remain the most vibrant field for the researchers in formulation science.
For liquisolid mixture, the endothermic peak of the drug completely disappeared indicating that the drug is completely solubilized and compzcts dispersed with excipients within liquisolid system. Compcats percentage drug release was calculated using an equation obtained from a calibration curve. The highest liquid factor copacts obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations.
Can’t read the image? The pronounced effect of the different carriers was not observed on dissolution profile so the flow properties and tensile strength were considered for optimizing the carrier. All prepared tablets complied with the pharmacopoeial required specifications for the weight variation and content uniformity tests.
To receive news and publication updates for Liquisoldi of Drug Delivery, enter your email address in the liqulsolid below. Formulations containing showed good flowability than formulations containing. The three principal suggested mechanisms include an increased surface area of drug particles, an increased aqueous solubility, and an improved wettability of the drug particles.
Formulation FA3 containing Fujicalin exhibited lower mean dissolution time and higher dissolution efficiency than all other formulations including marketed tablet.
Select your language of interest to view the total content in your interested language. Patil J Liquisolid Compact Technique: DSC was used for the investigation of any interaction between the drug and its excipients. This would explain the improved drug dissolution from liquisolid compared to conventional preparations. Solubility and dissolution are the core concepts of any physical or chemical science including biopharmaceutical and pharmacokinetic considerations in therapy of any medicine.
The appropriate amounts of carrier and coating materials used for each formulation depend upon of compadts formulation.
Visit for more related articles at Journal of Pharmacovigilance. A Novel Approach to Solubility Enhancement.
Solubility of olmesartan medoxomil was determined in various nonvolatile solvents. International Journal of ChemTech Research 2: This indicates coompacts there is no interaction between the drug and excipients. Formulated liquisolid compacts showed all physical parameters within prescribed limit.
Dissolution parameters of optimized liquisolid compacts compzcts conventional tablets of Olmesartan medoxomil. However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.
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The lowest liquid factor was obtained for Avicel PHand accordingly, the amount of carrier was higher than other formulations. At higher values the greater amount of carrier may overcome to some extent the flow properties of powder. Subscribe to Table of Contents Alerts. It is highly lipophilic log P 5.
Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
Spireas S Liquisolid systems and methods of preparing same. Inert, preferably water-miscible organic solvent systems with high boiling point and a not highly viscous organic solvent system such as propylene glycol, liquid polyethylene glycols, polysorbates, fixed oils, or glycerine are best suitable as liquid vehicles [ 5 ].
Hence, the liquisolid technology allows the conversion of liquid systems into solid drug delivery systems such as tablets. Permissions beyond the scope of this license may be available with editor ijper.
Concentration of dissolved drug was determined using standard equation. The hardness of the tablets was determined using Monsanto hardness tester. The liquisolid approach is a potential technology due to its simplified manufacturing method, cheaper production costs and the prospect of industrial scale up due to the good flow and compaction properties. Liquisold 19, Accepted: Composition of liquids solid compacts batches is shown in Table 1.